Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with α-ketones

• Ya-Ping Xiao,
• Xin-Yuan Liu and
• Chi-Ming Che

Beilstein J. Org. Chem. 2011, 7, 1100–1107, doi:10.3762/bjoc.7.126

• Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China 10.3762/bjoc.7.126 Abstract The gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular

• AgClO4 catalyzed intermolecular N-Michael addition and the subsequent gold(I)-catalyzed hydroalkylation is proposed. Keywords: cascade; cocatalyzed; gold(I)-catalyzed; intramolecular hydroalkylation; intermolecular N-Michael addition; pyrrolidine; silver(I)-catalyzed; Introduction Gold complexes are

• cascade intermolecular N-Michael addition/intramolecular hydroalkylation process. A variety of pyrrolidine compounds were conveniently prepared in moderate to excellent yields and with moderate to good diastereoselectivities from the simple starting materials. More recently, we have reported that gold(I